stubborn
unmanageable
not responding to treatment
SYN - stubborn
"a refractory case of acne"
temporarily unresponsive or not fully responsive to nervous or sexual stimuli
ANT - manipulable, tractable
"the refractory period of a muscle fiber"
stubbornly resistant to authority or control
SYN - fractious, recalcitrant
"a refractory child"
"It was a refractory obstacle which they would have to go around."
"He had such a refractory attitude towards his superiors that it was near impossible for him to get a reference."
"She had taken such a refractory stance on abortion that it was damn near impossible for her to see the other side of the problem."
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